From Adipose Tissue to Exosomes: a Journey to the Core of Regeneration

Adipose tissue as a biological goldmine

Over the last twenty years, studies have demonstrated that adipose tissue is the most accessible and abundant source of mesenchymal stromal cells (ADSC).
Compared to bone marrow, adipose tissue offers a minimally invasive harvesting procedure, a higher cell concentration and phenotypic stability.
From this evidence came Dual Trend's intuition: using the patient's own fat as a biological raw material to generate an autologous exosomal preparation.

From MSCa to molecular messengers

Adipose stem cells do not act primarily through differentiation, but through the secretion of extracellular vesicles (exosomes).
These micro-vesicles, measuring 30–150 nm, transport miRNA, mRNA, proteins, growth factors and bioactive lipids that coordinate tissue repair and regeneration.

ADSC-derived exosomes have shown positive effects in several fields:

• Dermatology and anti-ageing – they stimulate fibroblasts and type I collagen, reducing wrinkles and scars.

• Orthopaedics – they accelerate tendon and cartilage healing.

• Gynaecology – they support endometrial regeneration and fertility.

The role of the MilliExo® protocol

The MilliExo® system translates this knowledge into clinical practice thanks to a standardised sequence:

• Controlled harvesting with a 16 G needle to preserve cell vitality.

• Natural decantation without centrifugation, to separate vital fractions.

• Tonnard micro-fragmentation to release MSCa and pericytes.

• Selective filtration to obtain a purified micro-filtrate.

• Activation in hypoxia + ~37 °C inside the MilliExo Lab®.

The final result is a suspension of functional autologous exosomes, ready for clinical use.

Why it is a revolution

Unlike many heterologous treatments or centrifugation-based methods, MilliExo® guarantees:

• Full autology of the biological material

• No enzymes, solvents or chemical reagents

• Process repeatability and consistent quality

• Maximum biocompatibility with the patient

From cell to signal, from biology to clinical practice: MilliExo® is the bridge between science and medicine.
An intelligent system that harnesses the natural power of ADSC for autologous regeneration — safe, compliant and scientifically validated.